A Urinary Proteomics Approach to Predict Treatment Response in Acute Antibody-Mediated Rejection
نویسندگان
چکیده
Acute antibody-mediated rejection (AMR) is a severe complication affecting kidney allografts' long-term survival. Timely detection and appropriate treatment of AMR are crucial for improving graft outcomes. This study aimed to discover non-invasive urinary biomarkers that can predict the response therapy in patients with AMR. Materials Methods: In this case-control study, urine samples from 21 biopsy-proven underwent proteomics using label-free quantification. The were divided into two groups: responders non-responders based on their function. Urinary proteins identified, expressions compared between groups identify potential candidate biomarkers. Out 1020 identified proteins, 257 found be differentially expressed groups. Among these, 153 showed increased expression non-responder patients, while 104 decreased expression. Non-responder exhibited higher activation complement pathway extracellular matrix degradation than responders. Insulin-like growth factor binding protein 6 (IGFBP-6) emerged as most sensitive specific biomarker predicting non-response Our has successfully proteome distinguish These associated various biological processes reflect pathogenesis severity Further research necessary validate these findings.
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ژورنال
عنوان ژورنال: OBM transplantation
سال: 2023
ISSN: ['2577-5820']
DOI: https://doi.org/10.21926/obm.transplant.2303196